Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF)
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چکیده
منابع مشابه
Circulating Kidney Injury Molecule-1 Levels in Acute Heart Failure: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).
OBJECTIVES This study sought to determine the relationship of KIM-1 levels with adverse clinical outcomes in acute decompensated heart failure (ADHF). BACKGROUND Kidney injury molecule (KIM)-1 is a biomarker expressed by the nephron in acute tubular injury, and is a sensitive and specific marker for early acute kidney injury. Although commonly measured in urine, KIM-1 levels are also detectab...
متن کاملAcute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial
BACKGROUND Patients with acute heart failure (AHF) frequently have atrial fibrillation (AF), but how this affects patient-reported outcomes has not been well characterized. METHODS AND RESULTS We examined dyspnea improvement and clinical outcomes in 7007 patients in the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial. At baseline, 2677 (38....
متن کاملArrival by ambulance in acute heart failure: insights into the mode of presentation from Acute Studies of Nesiritide in Decompensated Heart Failure (ASCEND-HF).
OBJECTIVES Limited data exist assessing the relationship between ambulance versus self-presentation and outcomes in patients with acute heart failure (AHF). SETTING Clinical trial sites in North America. PARTICIPANTS 1068 patients enrolled in the Acute Studies of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial. PRIMARY AND SECONDARY OUTCOME MEASURES The association between amb...
متن کاملNesiritide in acute decompensated heart failure.
To the Editor: In an editorial accompanying an article by O’Connor et al.1 on the effect of nesiritide in patients with acute decompensated heart failure (July 7 issue), Topol2 describes the meandering path of nesiritide from approval by the Food and Drug Administration (FDA) on the basis of limited data through an ultimately disappointing pivotal trial. This discussion of the unfortunate legac...
متن کاملRenal subanalysis of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF): the end of nesiritide as a cardiorenal therapeutic?
O ver the last 3 decades, there has been a remarkable explosion in our understanding of the natriuretic pep-tide system. Among articles published before 1980, only 1 entry can be found in Medline under the search term natri-uretic peptide. Currently, however, there are >22 500 publications. In this impressive collection of literature, the concept of the natriuretic peptide as an ideal cardioren...
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ژورنال
عنوان ژورنال: American Heart Journal
سال: 2015
ISSN: 0002-8703
DOI: 10.1016/j.ahj.2015.04.007